Chondroitin Sulfate Elicits Systemic Pathogenesis In Mice By Interfering With Gut Microbiota Homeostasis
نویسندگان
چکیده
Tao Liao1,3, Yan-Ping Chen1,3, Shui-Qing Huang4, Li-Li Tan1, Chang-Qing Li1, Xin-An Huang1, Qin Xu1, Qi Wang2**, Qing-Ping Zeng1** 1Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. 2Clinical Pharmacology Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405 China. 3Basic Medical Science College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. 4These authors contributed equally. **Correspondence: [email protected]; [email protected]
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Chondroitin Sulfate Flourishes Gut Sulfatase-Secreting Bacteria To Damage Mucus Layers, Leak Bacterial Debris, And Trigger Inflammatory Lesions In Mice
Background: An interaction of the food types with the gut microbiota changes is deeply implicated in human health and disease. To verify whether animal-based diets would lead to gut dysbiosis, systemic inflammation and inflammatory pathogenesis, we fed mice with chondroitin sulfate (CS), a sulfate-containing O-glycan naturally occurring in livestock and poultry products, and monitored the dynam...
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